“This study is the first to show the efficacy of a PD-1 immune checkpoint inhibitor in this particular patient population. Published today in Nature (2), the KEYNOTE-811 Investigators including VHIO’s Director, Josep Tabernero, report results from the interim analysis of the first 264 patients who were randomly assigned 1:1 to receive pembrolizumab or placebo in combination with trastuzumab and chemotherapy.ĭata show that the objective response rate was 74.4% in the pembrolizumab arm and 51.9% in the placebo arm, which represents a 22.7% improvement versus trastuzumab and chemotherapy, and supports preclinical data suggesting a possible synergy between dual HER2 and PD1 blockade. Janjigian, Chief of the Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center (MSKCC, New York, USA), was designed to further assess this novel triplet combination in this patient population. Previous phase II studies combining PD-1 antibody pembrolizumab with trastuzumab and chemotherapy have shown increased clinical efficacy and a manageable safety profile in patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma.īuilding on these encouraging results, the randomized, double-blind, global phase III KEYNOTE-811 trial, led by Yelena Y. KEYNOTE-811: ringing in IO-based therapy for HER2+ gastric cancer For over a decade, the combination of anti-HER2 antibody trastuzumab and chemotherapy has constituted the standard first-line treatment for patients with HER2-positive disease. Ranking fifth for cancer incidence and fourth for cancer mortality, with an estimated 769,000 deaths globally in 2020, this tumor type represents a major healthcare challenge.Īpproximately 20% of advanced gastric and gastroesophageal junction cancers have overexpression or amplification of human epidermal growth factor receptor 2 ( HER2), which associates with a poor prognosis and increased disease recurrence and mortality. This study, upon completion, could lead to a paradigm shift in the treatment of patients with locally advanced unresectable or metastatic HER2+ gastric or gastroesophageal junction adenocarcinoma.Īccording to a recent report (1) gastric cancer is responsible for over one million new cases worldwide in 2020, with an increasing incidence among young adults (aged <50 years). Published in Nature, results of the interim analysis show that this novel triplet combination markedly reduces tumor size, induces a complete response in some patients, and significantly improves objective response.
#Keynote 811 trial#
The Procurement Analyst will support the sourcing category manager-assisting with negotiations, analysis, project execution and other tasks in support of.Image: Josep Tabernero, Director, Vall d'Hebron Institute of Oncology (VHIO), Head, Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain view moreĬredit: Vall d'Hebron Institute of Oncology Initial findings of the phase III KEYNOTE-811 trial of pembrolizumab plus trastuzumab and chemotherapy -first presented at ASCO 2021- led to the subsequent FDA approval of this combination for the first-line treatment of patients with HER2+ gastric cancer. Atlanta, Georgia, United States Supply Chain & Manufacturing Operations Job Id: 2203797. Newell Brands Recognized as a Trusted Company and. Mental Health Awareness Month: Supporting Our People and Our Communities. Newell Creative Kitchen is Hub for Innovation, Inspiration, Connection. Newell Brands Celebrates Diversity, Inclusion and Belonging Throughout May.
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#Keynote 811 series#
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